Neurobiology of Disease Role of GluK1 Kainate Receptors in Seizures, Epileptic Discharges, and Epileptogenesis
نویسندگان
چکیده
Brita Fritsch,1,2 Janine Reis,1,2 Maciej Gasior,1 Rafal M. Kaminski,1 and Michael A. Rogawski1,3 1Epilepsy Research Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, 2Department of Neurology, University Hospital, 79106 Freiburg, Germany, and 3Department of Neurology, School of Medicine and Center for Neuroscience, University of California, Davis, Sacramento, California 20817
منابع مشابه
Role of GluK1 kainate receptors in seizures, epileptic discharges, and epileptogenesis.
Kainate receptors containing the GluK1 subunit have an impact on excitatory and inhibitory neurotransmission in brain regions, such as the amygdala and hippocampus, which are relevant to seizures and epilepsy. Here we used 2-amino-3-(3-hydroxy-5-tert-butylisoxazol-4-yl) propanoic acid (ATPA), a potent and selective agonist of kainate receptors that include the GluK1 subunit, in conjunction with...
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